My husband has SEVERE small nerve fiber neuropathy due to Agent Orange in Vietnam. He is way beyond some minor tingling and numbness. There are a lot of different vitamins out there that help. Believe me, we have tried them all! This one, thus far seems to be the best. The one drawback is the price, it could be a tad lower in order to compete, but when you find something that gives some relief to someone as ill as my husband you do what you have to do.Neuropathy is complex though and it takes more than this to relieve the pain. Medication from a doctor is the MAIN help. Do NOT let a doctor prescribe opioids though.. that is a horrible road that leads to more pain ironically. Please believe me on that as I know first hand. Lyrica or Gabapentin are best accompanied with an anti depressant that for some reason aids the effect of either of those meds.I would like to add that besides the neuropathy, my husband received a host of other health issues due to Agent Orange in Vietnam. Sad.